CAFFEINE AND PROPRANOLOL BLOCK THE INCREASE IN RAT PINEAL MELATONIN PRODUCTION PRODUCED BY STIMULATION OF ADENOSINE RECEPTORS

被引：13

作者：

BABEY, AM

PALMOUR, RM

YOUNG, SN

机构：

[1] MCGILL UNIV,DEPT BIOL,MONTREAL H3A 1A1,PQ,CANADA

[2] MCGILL UNIV,DEPT PSYCHIAT,MONTREAL H3A 1A1,PQ,CANADA

[3] MCGILL UNIV,DEPT HUMAN GENET,MONTREAL H3A 1A1,PQ,CANADA

[4] MCGILL UNIV,SCH DIETET & HUMAN NUTR,MONTREAL H3A 1A1,PQ,CANADA

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

基金：

英国医学研究理事会;

关键词：

ADENOSINE RECEPTOR; MELATONIN; PINEAL GLAND; PROPRANOLOL; RAT; 5'-N-ETHYLCARBOXAMIDOADENOSINE;

D O I：

10.1016/0304-3940(94)90879-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA) injected i.p. during the light period increased rat pineal melatonin levels and this increase was blocked by simultaneous administration of the non-selective adenosine receptor antagonist caffeine. A single dose of the adenosine A(1) agonist cyclopentyladenosine had no effect on nocturnal melatonin production. The NECA-stimulated increase was also blocked by the beta-adrenergic receptor antagonist propranolol. Given alone, neither caffeine nor propranolol had any effect on melatonin levels. The results point to an intermediate role for beta-adrenergic receptors in the adenosine-stimulated increase of melatonin production.

引用

收藏

页码：93 / 96

页数：4

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