PREPARATION OF N-HYDROXYAZOLES BY OXIDATION OF AZOLES

被引：41

作者：

BEGTRUP, M

VEDSO, P

机构：

[1] Department of Medicinal Chemistry, Royal Danish School of Pharmacy, DK-2100 Copenhagen

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 03期

关键词：

D O I：

10.1039/p19950000243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Azoles without N-substituents are oxidized with per-acids or perborate to the corresponding isomers separated through N-hydroxy substituted azoles. 1,2,4-Triazole and tetrazole produce two their O-benzyl derivatives. Imidazole and 1,2,3-and 1,2,4-triazole can be di-oxygenated in low yields. N-Hydroxypyrazole is deoxygenated by per-acid.

引用

页码：243 / 247

页数：5

共 28 条

[1]

Acheson R.M., 1990, ADV HETEROCYCL CHEM, V51, P105, DOI [DOI 10.1016/S0065-2725(08)60002-1, 10.1016/S0065-2725(08)60002-1]

[2]

BAUS U, 1990, Patent No. 3900347

[3]

BAUS U, 1991, Patent No. 420092

[4]

BAUS U, 1989, Patent No. 3820738

[5]

BAUS U, 1989, Patent No. 3820739

[6] SYNTHESIS AND REACTIONS OF 4-HYDROXY-1,2,4-TRIAZOLES [J].

BECKER, HGO ;

GORMAR, G ;

TIMPE, HJ .

JOURNAL FUR PRAKTISCHE CHEMIE, 1970, 312 (04) :610-&

[7] 2-SUBSTITUTED PYRAZOLE 1-OXIDES - PREPARATION AND REACTION WITH ELECTROPHILIC REAGENTS [J].

BEGTRUP, M ;

LARSEN, P ;

VEDSO, P .

ACTA CHEMICA SCANDINAVICA, 1992, 46 (10) :972-980

[8] NMR-STUDIES IN THE HETEROCYCLIC SERIES .31. EFFECT OF N-SUBSTITUENTS ON THE C-13 NMR PARAMETERS OF AZOLES [J].

BEGTRUP, M ;

ELGUERO, J ;

FAURE, R ;

CAMPS, P ;

ESTOPA, C ;

ILAVSKY, D ;

FRUCHIER, A ;

MARZIN, C ;

DEMENDOZA, J .

MAGNETIC RESONANCE IN CHEMISTRY, 1988, 26 (02) :134-151

[9] 3-SUBSTITUTED 1,2,3-TRIAZOLE-1-OXIDES - PREPARATION AND REACTIONS [J].

BEGTRUP, M ;

JONSSON, G .

ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1987, 41 (10) :724-735

[10]

Bettinetti G.F., 1956, ANN CHIM-ROME, V46, P812

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