EVALUATION OF ANTITHROMBOTIC PROPERTIES OF SULOCTIDIL IN COMPARISON WITH ASPIRIN AND DIPYRIDAMOLE

被引：27

作者：

GUREWICH, V ^{[1
]}

LIPINSKI, B ^{[1
]}

机构：

[1] TUFTS UNIV, LEMUEL SHATTUCK HOSP, SCH MED, VASC LAB, BOSTON, MA 02130 USA

来源：

THROMBOSIS RESEARCH | 1976年 / 9卷 / 02期

关键词：

D O I：

10.1016/0049-3848(76)90154-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antithrombotic effect of suloctidil, a new antispasmotic with platelet anti-aggregating properties was evaluated in 2 rabbit models. In the first, thrombi were formed in polyethylene catheters placed in the lumens of the carotid arteries. Quantitation of the thrombi was achieved with radiolabeled fibrinogen. The antithrombotic effect of suloctidil was significantly greater than placebo or aspirin and insignificantly greater than i.v. administered dipyridamole. In the 2nd model, 2 appropriately spaced doses of endotoxin were given. Suloctidil did not inhibit the initial endotoxin induced consumption of platelets of WBC [leukocytes], but inhibited the 2nd fall in platelets believed related to thrombin elaboration. An accompanying slight inhibition of fibrin deposition and fibrinogen consumption was found.

引用

页码：101 / 108

页数：8

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