THE RIBONUCLEASE FROM AN EXTINCT BOVID RUMINANT

被引：66

作者：

STACKHOUSE, J ^{[1
]}

PRESNELL, SR ^{[1
]}

MCGEEHAN, GM ^{[1
]}

NAMBIAR, KP ^{[1
]}

BENNER, SA ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,ORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND

来源：

FEBS LETTERS | 1990年 / 262卷 / 01期

关键词：

Artiodactyla; Evolution; Parsimony; Protein engineering; Ribonuclease;

D O I：

10.1016/0014-5793(90)80164-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sequence of the ribonuclease from the ancestor of swamp buffalo, river buffalo, and ox, corresponding approximately to Pachyportax latidens, an extinct ruminant known from the fossil record, has been reconstructed using the rule of 'maximum parsimony'. This protein and two sequences that may have been intermediates in the evolution of modern ribonuclease have been constructed in the laboratory by site-directed mutagenesis, and their properties examined. © 1990.

引用

页码：104 / 106

页数：3

共 25 条

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