INHIBITION OF MEDIATOR RELEASE DURING THE EARLY REACTION TO ANTIGEN

被引:11
作者
NACLERIO, RM [1 ]
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV CLIN IMMUNOL,BALTIMORE,MD 21205
关键词
ALLERGIC RHINITIS; ANTIGEN; HISTAMINE; MAST CELL; CETIRIZINE; LORATADINE; TERFENADINE;
D O I
10.1016/0091-6749(92)90157-W
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
A nasal lavage model and a new filter paper disk model have been used to measure biologic and physiologic responses to antigen challenge in patients with allergic rhinitis. Pretreatment Of subjects with cetirizine reduced the number of sneezes induced by antigen challenge but did not significantly reduce levels of histamine or prostaglandin D2 in a double-blind, placebo-controlled trial with the lavage model. Pretreatment with 60 or 300 mg of terfenadine did significantly reduce levels of histamine, kinin, albumin, and TAME-esterase activity in a double-blind, placebo-controlled study with this model. Again with the nasal lavage model, a double-blind, placebo-controlled comparison of pretreatment with 60 mg of terfenadine or 10 mg of loratadine showed that both agents significantly reduced sneezing. Both drugs also lowered levels of antigen-induced histamine and TAME-esterase, but only terfenadine did so significantly. In a double-blind, placebo-controlled study, the new disk method showed that terfenadine reduced sneezing but not nasal congestion in eight patients with allergic rhinitis. Terfenadine significantly reduced the weight of nasal secretions on both sides of the nose and significantly reduced histamine on the ipsilateral side.
引用
收藏
页码:715 / 719
页数:5
相关论文
共 2 条
[1]   TERFENADINE, AN H-1 ANTIHISTAMINE, INHIBITS HISTAMINE-RELEASE INVIVO IN THE HUMAN [J].
NACLERIO, RM ;
KAGEYSOBOTKA, A ;
LICHTENSTEIN, LM ;
FRIEDHOFF, L ;
PROUD, D .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (01) :167-171
[2]  
NACLERIO RM, 1989, LARYNGOSCOPE, V99, P596