ANALYSIS OF THE EFFECT OF INTRAVESICAL TREATMENT WITH INTERFERON-ALPHA-2B ON THE CLINICAL EVOLUTION AND ON THE INVIVO FUNCTION OF LYMPHOCYTES-T AND NATURAL-KILLER-CELLS IN PATIENTS WITH SUPERFICIAL BLADDER-TUMORS

被引：4

作者：

CARBALLIDO, J ^{[1
]}

MOLTO, LM ^{[1
]}

OLIVIER, C ^{[1
]}

MANZANO, L ^{[1
]}

ALVAREZMON, M ^{[1
]}

机构：

[1] UNIV ALCALA DE HENARES, DEPT MED, ALCALA DE HENARES, SPAIN

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷

关键词：

BLADDER CANCER; INTRAVESICAL THERAPY; INTERFERON-ALPHA-2B; NATURAL KILLER CELLS; LYMPHOCYTES-T; IMMUNOREACTIVITY;

D O I：

10.1097/00001813-199205000-00003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following complete transurethral resection, patients with superficial transitional cell carcinoma (TCC) were treated with intravesical interferon-alpha-2b. Ex vivo analysis of peripheral blood mononuclear cells (PBMNC) both during and after the treatment period showed an enhancement of natural killer (NK) activity which fell to basal levels upon cessation of therapy. Simultaneous analysis of T-cell activity revealed a similar pattern of variation in the response to the polyclonal mitogen phytohemagglutinin. Both findings point to an alteration in systemic immunoreactivity as a result of intravesical treatment. Further work will be aimed at determining whether this is relevant to the therapeutic value of such treatment and whether prolonged treatment will maintain these effects.

引用

页码：9 / 12

页数：4

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