PROTEIN KINASE-A INHIBITORS PREVENT THE MAINTENANCE OF HIPPOCAMPAL LONG-TERM POTENTIATION

被引：133

作者：

MATTHIES, H ^{[1
]}

REYMANN, KG ^{[1
]}

机构：

[1] INST NEUROBIOL,DEPT NEUROPHYSIOL,PSF 1860,O-3010 MAGDEBURG,GERMANY

来源：

NEUROREPORT | 1993年 / 4卷 / 06期

关键词：

SYNAPTIC PLASTICITY; LONG-TERM POTENTIATION; HIPPOCAMPUS; DOPAMINE; PROTEIN KINASE-A; INHIBITORS; H-8; RP-CAMPS;

D O I：

10.1097/00001756-199306000-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE possible involvement of cAMP-dependent protein kinase A (PKA) in mechanisms of long-term potentiation of the Schaffer collateral-commissural input of rat CA1 neurones was investigated using several inhibitors in vitro. If 10 muM H-8, 100 nM KT5720 or 50 muM Rp-cAMPS was applied to the bath before a triple 100 Hz/0.5 s tetanization, post-tetanic and short-term potentiation developed almost normally. However, from about 3 h after tetanization the long-term potentiation (LTP) of the field-EPSP declined with respect to the control in an irreversible manner. These data suggest that besides protein kinase C the synergistic activation of PKA is necessary for the maintenance of LTP.

引用

页码：712 / 714

页数：3

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