SYNTHESIS OF ALPHA-2'-DEOXYNUCLEOSIDES

被引：5

作者：

LARSEN, E

ALEEM, AAHA

PEDERSEN, EB

机构：

[1] Department of Chemistry, Odense University, Odense, DK-5230

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 05期

关键词：

D O I：

10.1002/jhet.5570320542

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Thymidine (4) was synthesized from thymidine (1) in 3 steps in 36% overall yield without using chromatography and with the possibility of increasing the yield to 85% by reusing the remaining alpha,beta-mixture. 1-(2-Deoxy-3,5-di-O-p-toluoyl-alpha-D-erythro-pentofuranosyl)thymine (3) was further converted to 1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-methylcytosine (5).

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页码：1645 / 1646

页数：2

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