TEMPORALLY CONTROLLED DRUG-DELIVERY SYSTEMS - COUPLING OF PH OSCILLATORS WITH MEMBRANE-DIFFUSION

被引:33
作者
GIANNOS, SA [1 ]
DINH, SM [1 ]
BERNER, B [1 ]
机构
[1] CIBA GEIGY CORP,TRANSDERMAL RES & EVALUAT,ARDSLEY,NY 10502
关键词
D O I
10.1002/jps.2600840505
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A novel approach to modulate the release of a drug or an active ingredient that avoids the need for external power sources or electronic controllers is described. By changing the pH of a solution relative to the pK(a), a drug, enhancer, or solubilizer may be rendered charged or uncharged. Because only the uncharged form of a drug can permeate across lipophilic membranes, a temporally modulated delivery profile may be obtained with a pH oscillator in the donor solution, Ionizable permeants have a buffer capacity, so the feasibility of coupling the mixed Landoldt pH oscillator with membrane diffusion of nicotine or benzoic acid is demonstrated for a single oscillation.
引用
收藏
页码:539 / 543
页数:5
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