Type 2 diabetes in children and adolescents

被引：14

作者：

Amed, Shazhan ^{[2
,3
]}

Daneman, Denis ^{[1
,4
]}

Mahmud, Farid H. ^{[4
,5
]}

Hamilton, Jill ^{[4
,5
]}

机构：

[1] Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada

[2] British Columbia Childrens Hosp, Dept Pediat, Endocrinol & Diabet Unit, Vancouver, BC, Canada

[3] Univ British Columbia, Vancouver, BC, Canada

[4] Univ Toronto, Toronto, ON M5G 1X8, Canada

[5] Hosp Sick Children, Dept Pediat, Div Endocrinol, Toronto, ON, Canada

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2010年 / 8卷 / 03期

关键词：

beta-cell function; insulin resistance; obesity; pediatrics; Type; 2; diabetes;

D O I：

10.1586/ERC.10.15

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The emergence of Type 2 diabetes (T2D) in children and adolescents parallels the rising rates of childhood obesity. As a condition of impaired insulin sensitivity and relative insulin deficiency resulting in hyperglycemia, T2D has a complex underlying physiology that is reflected by the multiple approaches used to optimize medical care and prevent the myriad of diabetes-related complications. T2D diagnosed in children and adolescents represents a distinct and challenging condition to evaluate and treat. Here, we highlight the epidemiology, pathophysiology, risk factors, clinical presentation and diagnosis, treatment and public health impact of T2D in children and adolescents.

引用

页码：393 / 406

页数：14

共 126 条

[1]

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].