EFFECT OF CYCLODEXTRINS ON THE CHEMICAL-STABILITY OF MITOMYCINS IN ALKALINE-SOLUTION

被引：9

作者：

BEKERS, O

BEIJNEN, JH

TANK, MJTK

BULT, A

UNDERBERG, WJM

机构：

[1] UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT ANAL,SORBONNELAAN 16,3584 CA UTRECHT,NETHERLANDS

[2] NETHERLANDS CANC INST,SLOTERVAART HOSP,1066 EC AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 10-12期

关键词：

MITOMYCINS; CYCLODEXTRINS; INCLUSION COMPLEXES; STABILIZATION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1016/0731-7085(91)80044-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The effects of cyclodextrins on the chemical stability of several mitomycin antibiotics in an alkaline medium have been investigated. A stability-indicating high-performance liquid chromatographic method was used to determine the overall degradation rate constants. The influence of various parameters such as structural variations of the cyclodextrins and mitomycins, temperature and pH was studied. It appears that complexation is most favourable with gamma-cyclodextrin. All mitomycin-gamma-cyclodextrin complexes degrade at lower rates than those of the free drugs. Moreover, it was shown that gamma-cyclodextrin influences the equilibrium between mitomycin C and its zwitterion mesomer.

引用

页码：1055 / 1060

页数：6

共 20 条

[1] THE INFLUENCE OF CYCLODEXTRIN COMPLEXATION ON THE STABILITY OF BETAMETHASONE-17-VALERATE [J].