CARCINOGENIC EFFECTS OF WOOD DUST - REVIEW AND DISCUSSION

被引:93
作者
NYLANDER, LA [1 ]
DEMENT, JM [1 ]
机构
[1] NIEHS,OFF OCCUPAT HLTH & TECH SERV,RES TRIANGLE PK,NC 27709
关键词
WOOD DUST; OCCUPATIONAL EXPOSURE; FURNITURE WORKERS; CARPENTERS; NASAL CANCER; OCCUPATIONAL DISEASE; TOXICITY; MUTAGENICITY; PREVENTION;
D O I
10.1002/ajim.4700240511
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Occupational exposure to wood dust (alone or chemically treated) is associated with an increased risk of developing adenocarcinoma of the nasal cavity. The specific causative agents, i.e., wood dust alone (natural products), wood dust with additives used in the processing or manufacturing of wood products, and/or physical determinants of wood dust and the associated risk factors, are not known or understood. The strongest association of exposure to wood dust and development of nasal cancer is observed in those occupations where workers are exposed to hard wood dust and chemical additives are not used. The time between first occupational exposure to wood dust and the development of adenocarcinoma of the nasal cavity averages 40 years (range 7-70 years). The epidemiological data available are not sufficient to make a definitive assessment between wood dust exposure and increased fisk for cancer other than nasal cancer. The toxicity, mutagenicity, and carcinogenicity of wood dust to laboratory animals or in vitro with animal or microbial cells have not been thoroughly studied. Thus there is no direct experimental evidence on the potential hazards of wood dust. Data are insufficient or lacking on 1) wood dust exposure levels in ambient air and worker's breathing zone, and the deposition in the nasal cavity; 2) hard vs. soft wood dusts; 3) particle size and shape; 4) chemical composition of wood dust and the extent of contamination with chemical additives; and 5) interaction between inhaled wood dust, chronic irritation, and tobacco smoking. These data are required so that one can understand the association between wood dust exposure and nasal cavity tumors, along with demographic differences in cancer rates, and to develop strategies for intervention and reduction of disease causing agents in order to reduce risk to wood industry workers. (C) 1993 Wiley-Liss, Inc.
引用
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页码:619 / 647
页数:29
相关论文
共 186 条
[1]  
ABRAMSON JH, 1978, J NATL CANCER I, V61, P307
[2]   MORTALITY OF ENGLISH FURNITURE MAKERS [J].
ACHESON, ED ;
PIPPARD, EC ;
WINTER, PD .
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1984, 10 (04) :211-217
[3]  
ACHESON ED, 1972, BRIT J IND MED, V29, P21
[4]   IS NASAL ADENOCARCINOMA IN THE BUCKINGHAMSHIRE FURNITURE INDUSTRY DECLINING [J].
ACHESON, ED ;
WINTER, PD ;
HADFIELD, E ;
MACBETH, RG .
NATURE, 1982, 299 (5880) :263-265
[5]  
ACHESON ED, 1981, BRIT J IND MED, V38, P218
[6]   NASAL CANCER IN WOODWORKERS IN FURNITURE INDUSTRY [J].
ACHESON, ED ;
COWDELL, RH ;
HADFIELD, E ;
MACBETH, RG .
BRITISH MEDICAL JOURNAL, 1968, 2 (5605) :587-&
[7]  
ACHESON ED, 1967, LANCET, V1, P311
[8]   NASAL CANCER IN FURNITURE AND BOOT AND SHOE MANUFACTURING-INDUSTRIES [J].
ACHESON, ED .
PREVENTIVE MEDICINE, 1976, 5 (02) :295-315
[9]  
ACHESON ED, 1983, ENCY OCCUPATIONAL HL, V2, P1426
[10]  
ACHESON ED, 1986, TOXICOLOGY NASAL PAS, P135