PARATHYROID-HORMONE ACTIVATION OF STRETCH-ACTIVATED CATION CHANNELS IN OSTEOSARCOMA CELLS (UMR-106.01)

被引：53

作者：

DUNCAN, RL

HRUSKA, KA

MISLER, S

机构：

[1] Renal Division, Department of Medicine, Jewish Hospital, St. Louis

来源：

FEBS LETTERS | 1992年 / 307卷 / 02期

关键词：

OSTEOBLASTIC CELL LINE; STRETCH-ACTIVATED CHANNEL; PARATHYROID HORMONE; CYCLIC AMP;

D O I：

10.1016/0014-5793(92)80771-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.

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页码：219 / 223

页数：5

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