GAMMA-INTERFERON, INTERLEUKIN-4 AND INTERLEUKIN-6 IN-VITRO PRODUCTION IN OLD SUBJECTS

被引：54

作者：

CANDORE, G ^{[1
]}

DILORENZO, G ^{[1
]}

MELLUSO, M ^{[1
]}

CIGNA, D ^{[1
]}

COLUCCI, AT ^{[1
]}

MODICA, MA ^{[1
]}

CARUSO, C ^{[1
]}

机构：

[1] UNIV PALERMO,IST PATOL GEN,I-90134 PALERMO,ITALY

来源：

AUTOIMMUNITY | 1993年 / 16卷 / 04期

关键词：

ELDERLY; GAMMA-IFN; IL-4; IL-6; T HELPER;

D O I：

10.3109/08916939309014646

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is well known that ageing is associated with various alterations of the lymphoid cell functions. Although both B and T cell are affected, the last appear to be more sensitive to ageing process. During the past years, to gain insight into the mechanism(s) of this impairment, effort has been centered on the helper T cells specifically engaged in the production of interleukin-2 (IL-2) because of the pivotal role played by this cytokine in the activation of several immune functions. The results have demonstrated that the ability to produce IL-2 declines with age. In this paper we report the results of a study performed to determine the influence of age on the capacity to produce gamma-interferon (gamma-IFN), interleukin-4 (IL-4) and interleukin-6 (IL-6). Mononuclear cells from young and old subjects were assessed for cytokine producing capacity in response to phytohaemoagglutinin stimulation. A significant decrease of gamma-IFN production by old subjects has been observed. No significant difference was instead observed between the old subjects and the young ones as regards IL-4 and IL-6 production. We suggest that this imbalanced cytokine production may well account for the pattern of immune response which may be observed in elderly, i.e. a normal or increased humoral response in face of a low T cell immune responsiveness.

引用

页码：275 / 280

页数：6

共 38 条

[1] Antonaci S., Jirillo E., Bonomo L., Immunoregulation in aging, Diagnostic Clin Immunol, 5, pp. 55-61, (1987)
[2] Thoman M.L., Weigle W.O., The cellular and subcellular bases of immunosenescence, Adv Immunol, 46, pp. 221-261, (1989)
[3] Gillis S., Kozak R., Durante M., Weksler M.E., Immunological studies of aging. Decreased production and response to T cell growth factor by lymphocytes from aged humans, J Clin Invest, 67, pp. 937-942, (1981)
[4] Smith K., Interleukin-2, Ann Rev Immunol, 2, pp. 319-333, (1984)
[5] Caruso C., Candore G., Cigna D., Colucci A.T., Modica M.A., Biological significance of soluble IL-2 receptor, Mediators of inflammation, 2, pp. 3-21, (1993)
[6] Caruso C., Di Lorenzo G., Modica M.A., Candore G., Portelli M.R., Crescimanno G., Ingrassia A., Barbagallo-Sangiorgi G., Salerno A., Soluble interleukin-2 receptor release defect in vitro in elderly subjects, Mech Ageing Develop 59, 59, pp. 27-35, (1991)
[7] Chopra R.K., Holbrook N.J., Powers D.C., McCoy M.T., Adler W.H., Nagel J.E., Interleukin 2, interleukin 2 receptor, and interferongamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans, Clin Immunol Immunopathol, 53, pp. 297-308, (1989)
[8] Farrar M.A., Schreiber R.D., The molecular cell biology of interferon-τ and its receptor, Annu Rev Immunol, 11, pp. 571-611, (1993)
[9] Paul W.E., Ohara J., B-cell stimulatory factor-1/interleukin 4, Annu Rev Immunol, 5, pp. 429-459, (1987)
[10] van Snick J., Interleukin-6:an overview, Annu Rev Immunol, 8, pp. 253-278, (1990)

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