TREATMENT OF PULMONARY DISEASED CAUSED BY MYCOBACTERIUM-KANSASII - RESULTS OF 18 VS 12 MONTHS CHEMOTHERAPY

被引：35

作者：

SAURET, J ^{[1
]}

HERNANDEZFLIX, S ^{[1
]}

CASTRO, E ^{[1
]}

HERNANDEZ, L ^{[1
]}

AUSINA, V ^{[1
]}

COLL, P ^{[1
]}

机构：

[1] HOSP SANTA CRUZ & SAN PABLO,SERV MICROBIOL,E-08025 BARCELONA,SPAIN

来源：

TUBERCLE AND LUNG DISEASE | 1995年 / 76卷 / 02期

关键词：

D O I：

10.1016/0962-8479(95)90550-2

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Setting: Chest Clinic, Sant Pau Hospital, Barcelona, Spain. Objective: To assess the therapeutic response of pulmonary disease due to Mycobacterium kansasii to 12 and 18 months of chemotherapy. Design: 28 patients with criteria of pulmonary disease caused by M. kansasii not associated with HIV-infection were identified in our department in the period 1985-91 (24 male, 4 female, mean age 56 +/- 12 years). 14 patients were treated with rifampicin-isoniazid-ethambutol daily for 12 months (ethambutol only for the first 6 months), and 14 with the same regimen for 18 months. The follow-up after treatment was 12-30 months. Results: All patients showed improvement of radiographic manifestation of disease and sputum conversion (mean time: 4.5 +/- 2 months). The adverse drug effects were minimal. No failures were detected, and only one patient (3,5%), in the group of 12-month chemotherapy, relapsed after finishing the treatment. Conclusions: Our findings suggest that pulmonary disease due to M. kansasii has an effective response to 12-month chemotherapy regimen and that it is not necessary to prolong the administration of ethambutol for more than 6 months.

引用

页码：104 / 108

页数：5

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