LOCALIZATION OF AN EPITOPE OF A CALCIUM-DEPENDENT MONOCLONAL-ANTIBODY TO THE N-TERMINAL REGION OF THE GLA DOMAIN OF HUMAN FACTOR-VII

被引：9

作者：

CHEUNG, WF

STAFFORD, DW

机构：

[1] UNIV N CAROLINA,DEPT BIOL,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,CTR THROMBOSIS & HEMOSTASIS,CHAPEL HILL,NC 27599

来源：

THROMBOSIS RESEARCH | 1995年 / 79卷 / 02期

关键词：

FACTOR VII; EPITOPE MAPPING;

D O I：

10.1016/0049-3848(95)00105-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The epitope of a calcium-dependent murine monoclonal antibody specific for human factor VII (Thim et.al., Biochemistry (1988) 27, 7785-7793) has been determined. Site-directed mutagenesis of residues 3 through 10 of factor VII eliminates the binding of this antibody but does not disturb the binding of a second antibody which binds nearby.

引用

页码：199 / 206

页数：8

共 40 条

[1] HIGH-AFFINITY, SPECIFIC FACTOR IXA BINDING TO PLATELETS IS MEDIATED IN PART BY RESIDUES-3-11 [J].