ADAPTATION OF THE GROWTH-HORMONE AND INSULIN-LIKE GROWTH-FACTOR-I AXIS TO CHRONIC AND SEVERE CALORIE OR PROTEIN-MALNUTRITION

被引：89

作者：

OSTER, MH ^{[1
]}

FIELDER, PJ ^{[1
]}

LEVIN, N ^{[1
]}

CRONIN, MJ ^{[1
]}

机构：

[1] GENENTECH INC, DEPT CELL BIOL & METAB, San Francisco, CA 94080 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1995年 / 95卷 / 05期

关键词：

BINDING PROTEINS; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; MALNUTRITION;

D O I：

10.1172/JCI117916

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The hierarchy of diet components (e,g,, protein, carbohydrate, vitamins, and minerals) influencing growth hormone (GH), insulin-like growth factor-I (IGF-I), and their binding proteins (BP) is not well defined. Young adult rats were fed diets for 1 mo that included low protein or 60% and 40% of carbohydrate calories. We hypothesized that levels of both hormones, their dominant BPs and Liver IGF-I mRNA would fall, and that part of the mechanism for decreasing serum IGP-I would be enhanced IGFBP-3 protease activity. By day 30, caloric deprivation to 40% lowered serum GH, GHBP, IGF-I and IGFBP-3, and liver IGF-I mRNA, This was the only condition resulting in body weight loss (-15%) vs 39% gain in controls. Restriction to 60% calories had no impact on BP levels, slightly lowered IGF-I (-12%) in the face of a 95% inhibition of GH levels, while allowing a modest 9% body weight gain. Protein deprivation lowered serum GH, IGF-I and IGFBP-3, and liver IGF-I mRNA, while GHBP levels were normal. The reduced total IGF-I under these dietary conditions could not be explained by an increase in IGFBP-3 protease activity, or a decrease in the association of IGF-I with IGFBP-3 and the acid labile subunit.

引用

页码：2258 / 2265

页数：8

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