A COMPARATIVE-STUDY OF THE ELECTROPHYSIOLOGIC EFFECTS OF STRIADYNE, ADENOSINE-TRIPHOSPHATE AND ADENOSINE IN THE CANINE HEART

被引：12

作者：

BELHASSEN, B ^{[1
]}

ILIA, R ^{[1
]}

PELLEG, A ^{[1
]}

GREENSPAN, A ^{[1
]}

HOROWITZ, L ^{[1
]}

机构：

[1] HAHNEMANN UNIV, LIKOFF CARDIOVASC INST, CARDIAC ELECTROPHYSIOL LAB, PHILADELPHIA, PA 19102 USA

来源：

CARDIOLOGY | 1985年 / 72卷 / 03期

关键词：

D O I：

10.1159/000173851

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The chronotropic and dromotropic effects of the intra-atrial administration of 0.97, 1.93 and 2.90 .mu.M/kg Striadyne, the pharmaceutical form of ATP for clinical use, ATP and adenosine, were compared in 13 anesthetized dogs. Striadyne, ATP and adenosine exerted transient dose-dependent negative chronotropic and dromotropic effects. There was no significant difference between the electrophysiologic effects of Striadyne and ATP which were significantly more pronounced than those of adenosine. Atropine (0.2 mg/kg) significantly attenuated the electrophysiologic effects of 2.90 .mu.M/kg Striadyne and ATP but not those of adenosine. Striadyne and ATP have similar electrophysiologic effects which are more pronounced than those of adenosine mainly due to vagal involvement in their mechanism of action.

引用

页码：113 / 122

页数：10

共 14 条

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