ENHANCING EFFECT OF CORTICOTROPIN-RELEASING NEUROHORMONE ON THE PRODUCTION OF INTERLEUKIN-1 AND INTERLEUKIN-2

被引：106

作者：

SINGH, VK

LEU, SJC

机构：

[1] Department of Biology, Biomedical Division, Developmental Center for Handicapped Persons, Logan

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 02期

关键词：

CORTICOTROPIN-RELEASING FACTOR; INTERLEUKIN PRODUCTION; NEUROIMMUNOMODULATION;

D O I：

10.1016/0304-3940(90)90025-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Based upon an immunomodulatory role for Corticotropin-Releasing Factor (CRF), a low molecular weight neurohormone, we investigated the effect of CRF on the production of interleukin-1 (IL-1) and interleukin-2 (IL-2) activities of mononuclear cells isolated from the peripheral blood of healthy subjects. The production of both IL-1 and IL-2 was stimulated by a nanomolar concentration of CRF by itself. In addition, CRF augmented the production of IL-1 as induced by lipopolysaccharide and the production of IL-2 as induced by phytohemagglutinin. These results suggest that CRF modulates the function of the cells of the immune system presumably by acting as a blood-borne mediator of the neuroendocrine-immune pathways.

引用

页码：151 / 154

页数：4

共 15 条

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