ACTIVITY OF SPANTIDE-I AND SPANTIDE-II AT VARIOUS TACHYKININ RECEPTORS AND NK-2 TACHYKININ RECEPTOR SUBTYPES

被引：24

作者：

MAGGI, CA ^{[1
]}

PATACCHINI, R ^{[1
]}

FENG, DM ^{[1
]}

FOLKERS, K ^{[1
]}

机构：

[1] UNIV TEXAS,INST BIOMED RES,AUSTIN,TX 78712

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 199卷 / 01期

关键词：

TACHYKININS; NK-1; RECEPTORS; TACHYKININ RECEPTOR SUBTYPES; PULMONARY ARTERY (RABBIT); TRACHEA (HAMSTER); (COMPETITIVE ANTAGONISTS);

D O I：

10.1016/0014-2999(91)90648-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We compared the ability of spantide I and II to antagonize tachykinins in monoreceptor bioassays. Both peptides antagonized the response to substance P methylester in the guinea-pig ileum (NK-1 receptor-mediated) with greater affinity than the responses mediated by NK-2 or NK-3 receptors in other bioassays. Spantide II was about 10 times more potent than spantide I as an NK-1 antagonist and also possessed some selectivity for the NK-2 receptor subtype present in the hamster trachea. Spantide II is a suitable tool to assess the role of NK-1 receptors in the central and peripheral nervous system.

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收藏

页码：127 / 129

页数：3

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