MICROINJECTION OF THE DOPAMINE ANTAGONIST CIS-FLUPENTIXOL INTO THE MPOA IMPAIRS COPULATION, PENILE REFLEXES AND SEXUAL MOTIVATION IN MALE-RATS

被引：95

作者：

WARNER, RK ^{[1
]}

THOMPSON, JT ^{[1
]}

MARKOWSKI, VP ^{[1
]}

LOUCKS, JA ^{[1
]}

BAZZETT, TJ ^{[1
]}

EATON, RC ^{[1
]}

HULL, EM ^{[1
]}

机构：

[1] SUNY BUFFALO,DEPT PSYCHOL,PK HALL,BUFFALO,NY 14260

来源：

BRAIN RESEARCH | 1991年 / 540卷 / 1-2期

关键词：

COPULATION; PENILE REFLEX; X-MAZE; FLUPENTIXOL; MEDIAL PREOPTIC AREA; RAT;

D O I：

10.1016/0006-8993(91)90505-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjection of the dopamine antagonist cis-flupenthixol into the medial preoptic area was previously shown to impair male rat copulatory behavior. The present experiments provide further evidence of cis-flupenthixol's inhibitory effects on male sexual behavior. Following microinjections of moderate to high doses of cis-flupenthixol, males exhibited slower copulatory rates and fewer ejaculations in copula, fewer ex copula erections and penile movements, and reduced sexual motivation in an X-maze. Locomotion in the X-maze was not significantly affected. Microinjections of the inactive isomer trans-flupenthixol produced no change in any behavioral measure, indicating that cis-flupenthixol's effects were receptor mediated. We suggest that dopamine receptors in the MPOA influence copulation primarily by regulating reflexive and motivational factors, but not locomotion.

引用

页码：177 / 182

页数：6

共 35 条

[1] DOPAMINE AUTORECEPTORS - PHARMACOLOGICAL CHARACTERIZATION BY MICROIONTOPHORETIC SINGLE CELL RECORDING STUDIES [J].