INTRAVENOUS IMMUNOGLOBULIN THERAPY OF AUTOIMMUNE AND SYSTEMIC INFLAMMATORY DISEASES

被引：75

作者：

RONDA, N

HUREZ, V

KAZATCHKINE, MD

机构：

[1] HOP BROUSSAIS,UNITE IMMUNOPATHOL,SERV IMMUNOL,96 RUE DIDOT,F-75674 PARIS 14,FRANCE

[2] HOP BROUSSAIS,INSERM,U28,F-75674 PARIS 14,FRANCE

来源：

VOX SANGUINIS | 1993年 / 64卷 / 02期

关键词：

D O I：

10.1111/j.1423-0410.1993.tb02521.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The proven beneficial effect of intravenous immunoglobulins (IVIg) in certain autoimmune disorders has led to the development of clinical trials in other autoimmune and systemic inflammatory diseases. In parallel, experimental studies are being carried out to better understand the mechanisms of action of IVIg. In this review, we discuss the clinical use of IVIg in autoimmune disorders and the possible mechanisms by which IVIg may be effective in the various diseases. A better understanding of the mechanisms of action of IVIg in autoimmune disease will allow optimization of their use as a therapeutic alternative to conventional immunosuppression.

引用

页码：65 / 72

页数：8

共 38 条

[1]

BASTA M, 1989, BLOOD, V74, P326

[2]

BERCHTOLD P, 1989, BLOOD, V74, P2414

[3] INTRAVENOUS TREATMENT WITH GAMMA-GLOBULIN IN ADULTS WITH IMMUNE THROMBOCYTOPENIC PURPURA - REVIEW OF THE LITERATURE [J].