ASYMMETRIC [2 + 2] CYCLOADDITION REACTION CATALYZED BY A CHIRAL TITANIUM REAGENT

被引：177

作者：

NARASAKA, K

HAYASHI, Y

SHIMADZU, H

NIIHATA, S

机构：

[1] Department of Chemistry, Faculty of Science, University of Tokyo, Tokyo 113, Hongo, Bunkyo-ku

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 23期

关键词：

D O I：

10.1021/ja00049a020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of certain Lewis acids, alkenes containing an alkylthio group (for example, ketene dithioacetals, alkenyl sulfides, alkynyl sulfides, and allenyl sulfides) react with electron deficient olefins to give the corresponding cyclobutane, cyclobutene, or methylene cyclobutane derivatives. By employing a chiral titanium catalyst generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral diol, the [2 + 2] cycloaddition reaction proceeds with high enantioselectivity.

引用

页码：8869 / 8885

页数：17

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