THE REGION OF THE ENVELOPE GENE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESPONSIBLE FOR DETERMINATION OF CELL TROPISM

被引：135

作者：

CANN, AJ

CHURCHER, MJ

BOYD, M

OBRIEN, W

ZHAO, JQ

ZACK, J

CHEN, ISY

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

[2] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 01期

关键词：

D O I：

10.1128/JVI.66.1.305-309.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Different isolates of human immunodeficiency virus type 1 (HIV-1) vary in the cell tropisms they display, i.e., the range of cell types in which they are able to establish a productive infection. Here, we report on the phenotypes of recombinants between two molecularly cloned strains of HIV-1. Our results prove that the envelope glycoprotein gp120 is solely responsible for the difference in cell tropism between the two parental isolates and that no other genes or sequences are involved in determining the cell tropism of these strains. The region of the envelope involved in the determination of cell tropism includes sequences which encode the V3 loop of gp120. Control of cell tropism by this region of the virus env gene is a general phenomenon which applies to many different HIV-1 isolates.

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页码：305 / 309

页数：5

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