AN IN-VITRO ASSAY UTILIZING PARASITIC LARVAL HAEMONCHUS-CONTORTUS TO DETECT RESISTANCE TO CLOSANTEL AND OTHER ANTHELMINTICS

被引:27
作者
ROTHWELL, JT
SANGSTER, NC
机构
[1] Department of Veterinary Pathology, University of Sydney
关键词
ANTHELMINTIC RESISTANCE; CLOSANTEL; H-CONTORTUS; IN-VITRO CULTURE; IVERMECTIN;
D O I
10.1016/0020-7519(93)90162-R
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
A new assay for detecting resistance to anthelmintics in vitro is described. The' assay uses a simple culture system in which the ability of anthelmintics to kill or inhibit the migration of parasitic third and fourth stage Haemonchus contortus larvae through a 50 pm aperture mesh is assessed. The assay detects 2-10-fold resistance to closantel. Resistance to benzimidazoles, levamisole and ivermectin can also be detected.
引用
收藏
页码:573 / 578
页数:6
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