APOLIPOPROTEIN-E TYPE EPSILON-4 ALLELE FREQUENCY IS NOT INCREASED IN PATIENTS WITH SPORADIC INCLUSION-BODY MYOSITIS

被引：29

作者：

HARRINGTON, CR ^{[1
]}

ANDERSON, JR ^{[1
]}

CHAN, KK ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT NEUROPATHOL,CAMBRIDGE CB2 2QW,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 183卷 / 1-2期

关键词：

APOLIPOPROTEIN E; INCLUSION BODY MYOSITIS; ALZHEIMERS DISEASE; TAU PROTEIN; AMYLOID BETA-PROTEIN;

D O I：

10.1016/0304-3940(94)11108-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The apolipoprotein E genotype was determined for 11 patients with sporadic inclusion-body myositis. Seven cases had the genotype epsilon 3/epsilon 3, the other four cases, epsilon 3/epsilon 4. The frequency of the epsilon 4 allele in this group of patients (0.182) was not significantly increased compared with elderly controls (0.147; n = 58), in contrast to Alzheimer's disease in which there was a significant increase (0.328; n = 67). The epsilon 2 allele was not found in any of the 11 sporadic inclusion-body myositis patients and its frequency was decreased in Alzheimer's disease. Despite certain pathological similarities that exist between inclusion body myositis and Alzheimer's disease, their association with particular apolipoprotein E genotypes is distinct.

引用

页码：35 / 38

页数：4

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