WALLABY TRANSTHYRETIN

被引：16

作者：

BRACK, CM ^{[1
]}

DUAN, W ^{[1
]}

HULBERT, AJ ^{[1
]}

SCHREIBER, G ^{[1
]}

机构：

[1] UNIV WOLLONGONG,DEPT BIOL SCI,WOLLONGONG,NSW 2522,AUSTRALIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1995年 / 110卷 / 03期

关键词：

AMINO ACID SEQUENCE; CDNA SEQUENCE; EVOLUTION; MARSUPIAL; PARSIMONY ANALYSIS; PHYLOGENY; PROTEIN STRUCTURE; TRANSTHYRETIN;

D O I：

10.1016/0305-0491(94)00200-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA library was constructed From liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site. Comparisons of nucleotide and amino acid sequences from several vertebrate species indicated that the greatest differences were in the region corresponding to the disordered N-terminus of mature human transthyretin. The evolutionary trees deduced from parsimony analyses of amino acid and nucleotide sequences of transthyretins, are consistent with that derived from fossil records.

引用

页码：523 / 529

页数：7

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