DENGUE-3 VIRUS-INFECTION OF AEDES-ALBOPICTUS AND AEDES-AEGYPTI - COMPARISON OF PARENT AND PROGENY CANDIDATE VACCINE VIRUSES

被引：12

作者：

SCHOEPP, RJ ^{[1
]}

BEATY, BJ ^{[1
]}

ECKELS, KH ^{[1
]}

机构：

[1] WALTER REED ARMY MED CTR,WASHINGTON,DC 20307

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 42卷 / 01期

关键词：

D O I：

10.4269/ajtmh.1990.42.89

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

DEN-3 parent (strain CH53489) and progeny candidate vaccine (clone 24/28) viruses were compared in their abilities to interact with Aedes aegypti and Ae. albopictus. The parent and progeny virus were equivalent in their ability to infect, to replicate in, and to be transmitted by both species of mosquitoes. The candidate vaccine DEN-3 clone was temperature sensitive and had small plaque morphology. These phenotypic markers remained stable during mosquito passage. Thus, temperature sensitivity and small plaque morphology are not reliable biological markers for attenuation.

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页码：89 / 96

页数：8

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