EFFECT OF HUMAN SEMINAL PLASMA ON THE LYTIC ACTIVITY OF NATURAL-KILLER-CELLS AND PRESUMPTIVE IDENTIFICATION OF PARTICIPANT MACROMOLECULES

被引：24

作者：

ABLIN, RJ ^{[1
]}

BARTKUS, JM ^{[1
]}

POLGAR, J ^{[1
]}

机构：

[1] LAJOS KOSSUTH UNIV,SCH MED,DEPT CLIN CHEM,H-4010 DEBRECEN,HUNGARY

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1990年 / 24卷 / 01期

关键词：

Immunoregulatory properties; immunosuppression; prostaglandins; seminal plasma; transglutaminase;

D O I：

10.1111/j.1600-0897.1990.tb00689.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

ABSTRACT: Using the lytic activity of natural killer (NK) cells as an in vitro parameter, the immunoregulatory properties of human seminal plasma (SeP1) and participant macromolecules have been investigated. Significant (P < 0.05) suppression of NK cell activity by SeP1 and chromatographically separable fractions was demonstrated in association with high and low molecular weight (Mr) macromolecules. SePl suppression was retained after heating to 56°C for 30 min, and appeared to function at the level of the effector, rather than target cell. Physicochemical characterization of high and low Mr fractions provided presumptive identification of the participation of transglutaminase and prostaglandins as the principal molecules contributory to SeP1 immunosuppression. 1990 Munksgaard

引用

页码：15 / 21

页数：7

共 43 条

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