CERVICAL PAPILLOMAVIRUSES SEGREGATE WITHIN MORPHOLOGICALLY DISTINCT PRECANCEROUS LESIONS

被引：236

作者：

CRUM, CP

MITAO, M

LEVINE, RU

SILVERSTEIN, S

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, CANC RES CTR, NEW YORK, NY 10032 USA

[2] COLUMBIA UNIV COLL PHYS & SURG, DEPT PATHOL, NEW YORK, NY 10032 USA

[3] COLUMBIA UNIV COLL PHYS & SURG, DEPT OBSTET & GYNECOL, NEW YORK, NY 10032 USA

[4] COLUMBIA UNIV COLL PHYS & SURG, DEPT MICROBIOL, NEW YORK, NY 10032 USA

[5] HIROSHIMA UNIV, SCH MED, DEPT OBSTET & GYNECOL, HIROSHIMA 730, JAPAN

来源：

JOURNAL OF VIROLOGY | 1985年 / 54卷 / 03期

关键词：

D O I：

10.1128/JVI.54.3.675-681.1985

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix were combined to correlate the presence of certain strains of human papillomaviruses (HPV) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV type 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPV.

引用

页码：675 / 681

页数：7

共 22 条

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