SYNTHESIS OF DINUCLEOSIDE PHOSPHATES CONTAINING SULFUR SUBSTITUTED NUCLEOBASES - 4-THIOURACIL, 4-THIOTHYMINE AND 6-MERCAPTOPURINE

被引：7

作者：

CLIVIO, P ^{[1
]}

FOURREY, JL ^{[1
]}

GASCHE, J ^{[1
]}

FAVRE, A ^{[1
]}

机构：

[1] CNRS,INST JACQUES MONOD,PHOTOBIOL MOLEC LAB,F-75251 PARIS 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 01期

关键词：

4-THIOURACIL; PROTECTION; PHOSPHORYLATION; NUCLEOSIDE;

D O I：

10.1016/S0040-4039(00)77675-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

S-pivaloyloxymethylation of sulfur substituted nucleobases enables the synthesis in solution of dinucleoside phosphates containing sulfur modified residues such as 4-thiouracil, 4-thiothymine and 6-mercaptopurine.

引用

页码：69 / 72

页数：4

共 16 条

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[J]. TETRAHEDRON LETTERS, 1991, 32 (26) : 3033 - 3034
[4] SYNTHESIS AND PROPERTIES OF OLIGONUCLEOTIDES CONTAINING 4-THIOTHYMIDINE, 5-METHYL-2-PYRIMIDINONE-1-BETA-D(2'-DEOXYRIBOSIDE) AND 2-THIOTHYMIDINE
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[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (13) : 4957 - 4974
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[6] FAVRE A, 1990, PHOTOCHEMISTRY NUCLE, V1, P399
[7] SEQUENCE DEPENDENT PHOTOCHEMISTRY OF DI(DEOXYNUCLEOSIDE) PHOSPHATES CONTAINING 4-THIOURACIL
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[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (18) : 1334 - 1336
[8] SYNTHESIS OF DNA VIA DEOXYNUCLEOSIDE H-PHOSPHONATE INTERMEDIATES
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[J]. NUCLEIC ACIDS RESEARCH, 1986, 14 (13) : 5399 - 5407
[9] GAREGG PJ, 1985, CHEM SCRIPTA, V25, P280
[10] LIPSETT MN, 1965, J BIOL CHEM, V240, P3975

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