THE IMPORTANCE OF DOPAMINE IN THE PATHOGENESIS OF EXPERIMENTAL PROLACTINOMAS

被引:11
作者
ELAZOUZI, M
HSU, DW
BLACK, PM
JOLESZ, F
HEDLEYWHYTE, ET
KLIBANSKI, A
ZERVAS, NT
机构
[1] BRIGHAM & WOMENS HOSP,NEUROSURG SERV,300 LONGWOOD AVE,BOSTON,MA 02115
[2] MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114
[3] CHILDRENS HOSP MED CTR,NEUROSURG SERV,BOSTON,MA 02115
[4] MASSACHUSETTS GEN HOSP,DIV NEUROPATHOL,BOSTON,MA 02114
[5] MASSACHUSETTS GEN HOSP,DIV ENDOCRINOL,BOSTON,MA 02114
[6] HARVARD UNIV,SCH MED,DEPT SURG,BOSTON,MA 02115
[7] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115
[8] HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115
[9] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
关键词
adenoma; diethylstilbestrol; dopamine; immunocytochemistry; pitu itary tumor; prolactin; rat; tyrosine hydroxylase;
D O I
10.3171/jns.1990.72.2.0273
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The factors responsible for the production of prolactin-secreting tumors are obscure. One hypothesis, that chronic loss of dopamine control from the hypothalamus may be associated with prolactinoma formation, was tested. Female adult Fischer 344 rats were subjected to ovariectomy and were then given subcutaneous implants of diethylstilbestrol (DES) Silastic capsules to produce lactotrophic hyperplasia. Sequential studies assessed the neuronal activity of the tuberoinfundibular dopaminergic neurons of the arcuate nucleus of the hypothalamus (A12) during and after this estrogen-induced pituitary growth. Immunocytochemical staining for tyrosine hydroxylase was used as a marker for dopamine synthesis, plasma radioimmunoassay provided plasma prolactin levels, and magnetic resonance imaging and histological studies were performed to examine the structural changes occurring in the pituitary gland. Animals were sacrificed from 3 to 67 days after DES implantation. To determine the reversibility of the estrogen-induced changes, rats were also sacrificed at different time intervxals after the removal of 30-, 40-, or 60-day DES implants. After 30 days of DES treatment, plasma prolactin levels increased 40-fold and pituitary weight increased more than threefold. Tyrosine hydroxylase immunoreactivity diminished gradually and was almost completely depleted at 30 days. Pituitary histology revealed marked prolactin cell hyperplasia. These changes were completely reversible; removal of the capsule after 30 days resulted in eventual normalization of plasma prolactin levels and pituitary size and in restoration of tyrosine hydroxylase immunoreactivity in the A12 region. Sixty days of DES treatment produced large hemorrhagic tumors with sustained high plasma prolactin levels and an irreversibly distorted A12 area. These observations suggest that in these animals loss of dopamine regulation secondary to estrogen stimulation initially produces prolactin hyperplasia but that prolonged loss leads to adenoma formation.
引用
收藏
页码:273 / 281
页数:9
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