MODEL USING A PEPTIDE WITH CARRIER FUNCTION FOR VACCINATION AGAINST DIFFERENT PATHOGENS

被引:14
作者
ETLINGER, HM
KNORR, R
机构
[1] Central Research Units, F. Hoffmann-La Roche Ltd
关键词
PEPTIDE; PREIMMUNIZATION; B-CELL; ANTIBODY; ADJUVANT;
D O I
10.1016/0264-410X(91)90038-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has been shown that pre-immunization with a protein can inhibit the antibody response to a new B-cell sequence which is coupled to the protein (epitope-specific suppression). By utilizing a peptide with carrier function from the protein, rather than the entire protein, the antibody response to the new B-cell sequence is enhanced in protein-primed mice. The present results extend this observation by showing that mice which have been pre-immunized with a protein followed by a B-cell sequence linked to a carrier peptide from the protein produce an enhanced antibody response to a new B-cell sequence linked to the same carrier peptide sequence. This indicates that it would be possible to reuse a carrier peptide sequence coupled with newly defined protective B-cell epitopes in a given individual to achieve immunity against new pathogens.
引用
收藏
页码:512 / 514
页数:3
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