REFINEMENT OF HUMAN CHROMOSOME-7 MAP AROUND THE PROALPHA2(I)COLLAGEN GENE BY LONG-RANGE RESTRICTION MAPPING

被引：6

作者：

KERE, J

TOLVANEN, R

DONISKELLER, H

DELACHAPELLE, A

机构：

[1] UNIV HELSINKI,DEPT MED GENET,SF-00290 HELSINKI 29,FINLAND

[2] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 10期

关键词：

D O I：

10.1093/nar/19.10.2755

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physical proximity of the closely linked proalpha2(1)collagen (COL1A2) and erythropoietin (EPO) genes and five loci with no known function was studied by long-range restriction mapping experiments using pulsed-field gel electrophoresis. COL1A2 and D7S64 were found to be within 100 kb of each other, providing a new informative marker for linkage studies with respect to COL1A2. D7S15 and D7S79 were within 350 kb of each other. The physical distance between COL1A2 and EPO was determined to be at least 600 kb. Two CpG rich islands were recognized within 600 kb of COL1A2, suggesting that other genes might lie in the vicinity of COL1A2.

引用

页码：2755 / 2759

页数：5

共 16 条

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