INTERCAPSULAR CATARACT-SURGERY WITH LENS EPITHELIAL-CELL REMOVAL .4. CAPSULAR FIBROSIS INDUCED BY POLY(METHYL METHACRYLATE)

被引：39

作者：

NISHI, O

NISHI, K

SAKKA, Y

SAKURABA, T

MAEDA, S

机构：

[1] The Nishi Eye Hospital, Osaka

[2] The Sakka Eye Clinic, Kitakyushu

[3] The Hirosaki University School of Medicine, Hirosaki-shi

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1991年 / 17卷 / 04期

关键词：

ANTERIOR CAPSULAR OPACIFICATION; FIBROUS METAPLASIA; LENS EPITHELIAL CELLS; POLY(METHYL METHACRYLATE);

D O I：

10.1016/S0886-3350(13)80854-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Characteristic lens epithelial cell behavior in the pseudophakic eye was examined by comparing 30 eyes that had extracapsular cataract surgery by the intercapsular technique and posterior chamber intraocular lens (IOL) implantation with lens epithelial cell removal but without anterior capsule capsulectomy and nine aphakic eyes that had the same procedure but without posterior chamber lens implantation over a mean follow-up period of 30 and 23 months, respectively. Fibrous anterior capsule opacification was observed in 83% of the pseudophakic eyes in the area of contact with the IOL, while the region beyond the margin of the IOL remained transparent. Fibrous anterior capsular opacification was not noted in the aphakic eyes. This suggests that the IOL material, poly(methyl methacrylate), stimulates lens epithelial cells to undergo fibrous metaplasia and to produce collagen fibers. Various cytokines such as IL-1 and TGF-beta-synthesized by lens epithelial cells may play a crucial role as mediators in the process. We recommend that this effect be considered as a parameter of biocompatibility in developing and evaluating new biomaterials.

引用

页码：471 / 477

页数：7

共 20 条

[1]

Apple DJ, Mamalis N, Reidy JJ, Et al., A comparison of ciliary sulcus and capsular bag fixation of posterior chamber intraocular lenses, Am Intra-Ocular Implant Soc J, 11, pp. 44-63, (1985)

[2]

Miyake K, Asakura M, Kobayashi H, Effect of intraocular lens fixation on the blood-aqueous barrier, Am J Ophthalmol, 98, pp. 451-455, (1984)

[3]

Nishi O, Intercapsular cataract surgery with lens epithelial cell removal. Part I: Without capsulorhexis, J Cataract Refract Surg, 15, pp. 297-300, (1989)

[4]

Hara T, Hara T, Clinical results of endocapsular phacoemulsification and complete in-the-bag intraocular lens fixation, J Cataract Refract Surg, 13, pp. 279-286, (1987)

[5]

Nishi O, Removal of lens epithelial cells by ultrasound in endocapsular cataract surgery, Ophthalmic Surg, 18, pp. 577-580, (1987)

[6]

Nishi O, Fibrinous membrane formation on the posterior chamber lens during the early postoperative period, J Cataract Refract Surg, 14, pp. 73-77, (1988)

[7]

Nishi O, Nishi K, Fibrin reaction following posterior chamber lens implantation, Implants Ophthalmol, 2, pp. 216-220, (1988)

[8]

Nishi O, Intercapsular cataract surgery with lens epithelial cell removal. Part II: Effect on prevention of fibrinous reaction, J Cataract Refract Surg, 15, pp. 301-303, (1989)

[9]

Miyake K, Maekubo K, Miyake Y, Nishi O, Pupillary fibrin membrane. A frequent early complication after posterior chamber lens implantation in Japan, Ophthalmology, 96, pp. 1228-1233, (1989)

[10]

Hara T, Hara T, Kojima M, Et al., Specular microscopy of the anterior lens capsule after endocapsular lens implantation, J Cataract Refract Surg, 14, pp. 533-540, (1988)

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