CHEMOENZYMATIC SYNTHESIS OF PHOSPHATIDYL-L-SERINE HYDROPEROXIDE

被引：4

作者：

BABA, N

AOISHI, A

SHIGETA, Y

NAKAJIMA, S

KANEKO, T

MATSUO, M

SHIMIZU, S

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, ITABASHI KU, TOKYO 173, JAPAN

[2] KYOTO UNIV, DEPT AGR CHEM, SAKYO KU, KYOTO 606, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1994年 / 58卷 / 10期

关键词：

D O I：

10.1271/bbb.58.1927

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1-Stearoyl-2-[15'-(S)-hydroperoxyicosatetraenoyl]-phosphoserine was synthesized for the first time by utilizing lipoxygenase-catalyzed hydroperoxidation, protection of the hydroperoxy group, DCC-mediated esterification and phospholipase D-catalyzed transphosphatidylation. A hydroxy form of this hydroperoxide was prepared by reducing the hydroperoxy group with triphenylphosphine. Unoxidized phosphatidylserine was also prepared as a reference compound.

引用

页码：1927 / 1928

页数：2

共 9 条

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BABA, N
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NAKAJIMA, S
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KANEKO, T
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NAKAJIMA, S
IWASA, J
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