D-2-family receptor distribution in human postmortem tissue: An autoradiographic study

被引:77
作者
Lahti, RA
Roberts, RC
Tamminga, CA
机构
[1] Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, 21228
关键词
dopamine; dopamine receptors; H-3]raclopride; H-3]YM-09151-2; H-3](+)-7-Hydroxy-DPAT; D2; D3; D4; human; postmortem;
D O I
10.1097/00001756-199512150-00015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE distribution throughout the normal human brain of the dopamine D-2-family of receptors were investigated autoradiographically. Three ligands were used, [H-3]-YM-09151-2 to define the D-2, D-3, D-4 receptors; [H-3]raclopride the D-2 D-3 receptors; and [H-3](+)-7-OH-DPAT, in the presence of GTP, demonstrates Dg distribution. [H-3]YM-09151-2 and [H-3]raclopride binding were highest in caudate (121 vs 130 fmol mg(-1)), putamen (96 vs 136 fmol mg(-1)), and nucleus accumbens (113 vs 120 fmol mg(-1)). [H-3]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg(-1)) and hippocampus (27 fmol mg(-1)). [H-3](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D-2 distribution is highest in putamen, caudate and nucleus accumbens; D-3 in the nucleus accumbens; D-4 receptor in cortical areas and hippocampus.
引用
收藏
页码:2505 / 2512
页数:8
相关论文
共 25 条
[1]   REDUCED NEURONAL SIZE IN POSTERIOR HIPPOCAMPUS OF SCHIZOPHRENIC-PATIENTS [J].
BENES, FM ;
SORENSEN, I ;
BIRD, ED .
SCHIZOPHRENIA BULLETIN, 1991, 17 (04) :597-608
[2]  
BOYSON SJ, 1986, J NEUROSCI, V6, P3177
[3]  
CASEY DE, 1991, BIOL PSYCHIAT, V29, pA144
[4]   MOLECULAR-BIOLOGY OF THE DOPAMINE-RECEPTORS [J].
CIVELLI, O ;
BUNZOW, JR ;
GRANDY, DK ;
ZHOU, QY ;
VANTOL, HHM .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1991, 207 (04) :277-286
[5]   LIMBIC PATHOLOGY IN SCHIZOPHRENIA - THE ENTORHINAL REGION - A MORPHOMETRIC STUDY [J].
FALKAI, P ;
BOGERTS, B ;
ROZUMEK, M .
BIOLOGICAL PSYCHIATRY, 1988, 24 (05) :515-521
[6]   AUTORADIOGRAPHIC DISTRIBUTION OF D-3-TYPE DOPAMINE-RECEPTORS IN HUMAN BRAIN USING [H-3] 7-HYDROXY-N,N-DI-N-PROPYL-2-AMINOTETRALIN [J].
HERROELEN, L ;
DEBACKER, JP ;
WILCZAK, N ;
FLAMEZ, A ;
VAUQUELIN, G ;
DEKEYSER, J .
BRAIN RESEARCH, 1994, 648 (02) :222-228
[7]  
KENAKIN TP, 1987, PHARM ANAL DRUG RECE, P211
[8]   IDENTIFICATION OF EXTRASTRIATAL DOPAMINE D2 RECEPTORS IN POSTMORTEM HUMAN BRAIN WITH [I-125] EPIDEPRIDE [J].
KESSLER, RM ;
WHETSELL, WO ;
ANSARI, MS ;
VOTAW, JR ;
DEPAULIS, T ;
CLANTON, JA ;
SCHMIDT, DE ;
MASON, NS ;
MANNING, RG .
BRAIN RESEARCH, 1993, 609 (1-2) :237-243
[9]   DIFFERENT LAMINAR DISTRIBUTIONS OF DOPAMINE-D1 AND DOPAMINE-D2 RECEPTORS IN THE RAT HIPPOCAMPAL REGION [J].
KOHLER, C ;
ERICSON, H ;
RADESATER, AC .
NEUROSCIENCE LETTERS, 1991, 126 (02) :107-109
[10]   DOPAMINE-D(4) VERSUS DOPAMINE D(2) RECEPTOR SELECTIVITY OF DOPAMINE RECEPTOR ANTAGONISTS - POSSIBLE THERAPEUTIC IMPLICATIONS [J].
LAHTI, RA ;
EVANS, DL ;
STRATMAN, NC ;
FIGUR, LM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 236 (03) :483-486