Coronary microvascular dysfunction in women: an overview of diagnostic strategies

被引：36

作者：

Kuruvilla, Sujith ^{[1
]}

Kramer, Christopher M. ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, Dept Med Cardiol, Charlottesville, VA 22903 USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2013年 / 11卷 / 11期

关键词：

cardiac magnetic resonance; coronary microvascular dysfunction; diagnosis; myocardial perfusion reserve;

D O I：

10.1586/14779072.2013.833854

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary microvascular dysfunction (CMD) also known as syndrome X, is characterized by typical anginal symptoms, evidence of myocardial ischemia on non-invasive testing and normal to minimal coronary disease on coronary angiography. It has a female preponderance and has been detected in up to 50% of women presenting with chest pain symptoms. Definitive diagnosis of CMD is critical as recent evidence suggests that women with this condition are at increased risk of cardiovascular events in the future. Invasive coronary reactivity testing on coronary angiography is considered to be the 'gold standard' for diagnosis of CMD. Non-invasive imaging techniques such as PET and cardiac magnetic resonance hold promise for detection of CMD in the future.

引用

页码：1515 / 1525

页数：11

共 74 条

[1]

Phan A., Shufelt C., Merz C.N., Persistent chest pain and no obstructive coronary artery disease, JAMA, 301, 14, pp. 1468-1474, (2009)

[2]

Johnson B.D., Shaw L.J., Pepine C.J., Et al., Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: Results from the nih-nhlbi-sponsored women's ischemia syndrome evaluation (wise) study, Eur. Heart J., 27, 12, pp. 1408-1415, (2006)

[3]

Cannon III R.O., Epstein S.E., Microvascular angina as a cause of chest pain with angiographically normal coronary arteries, Am. J. Cardiol, 61, 15, pp. 1338-1343, (1988)

[4]

Jones E., Eteiba W., Merz N.B., Cardiac syndrome X and microvascular coronary dysfunction, Trends Cardiovasc. Med, 22, 6, pp. 161-168, (2012)

[5]

Kothawade K., Bairey Merz C.N., Microvascular coronary dysfunction in women: Pathophysiology, diagnosis, and management, Curr. Probl. Cardiol, 36, 8, pp. 291-318, (2011)

[6]

Marroquin O.C., Holubkov R., Edmundowicz D., Et al., Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: Implications for clinical practice, Am. Heart J., 145, 4, pp. 628-635, (2003)

[7]

Opherk D., Zebe H., Weihe E., Et al., Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms, Circulation, 63, 4, pp. 817-825, (1981)

[8]

Burke A.P., Farb A., Malcom G.T., Et al., Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women, Circulation, 97, 21, pp. 2110-2116, (1998)

[9]

Lanza G.A., Giordano A., Pristipino C., Et al., Abnormal cardiac adrenergic nerve function in patients with syndrome X detected by [123I] metaiodobenzylguanidine myocardial scintigraphy, Circulation, 96, 3, pp. 821-826, (1997)

[10]

Gulli G., Cemin R., Pancera P., Et al., Evidence of parasympathetic impairment in some patients with cardiac syndrome X, Cardiovasc. Res, 52, 2, pp. 208-216, (2001)

← 1 2 3 4 5 6 7 8 →