COMPARISON OF URINARY PHOSPHATE URATE AND MAGNESIUM EXCRETION FOLLOWING PARATHYROID HORMONE ADMINISTRATION TO NORMAL MAN

A phosphaturic dose of parathyroid hormone (PTH) administered intravenously to 14 normal volunteers significantly decreased magnesium excretion and did not significantly alter urate excretion. Elevated plasma levels of endogenous PTH appear to mediate the increased excretion of phosphate per nephron observed in progressive chronic renal disease. In this setting, a similar pattern of urate and magnesium excretion is seen. Results of this study fail to support the concept that PTH might play a role in the enhanced urate and magnesium excretion per nephron of subjects with chronic renal failure. © 1969.