CLONING AND DOMAIN-STRUCTURE OF THE MAMMALIAN SPLICING FACTOR U2AF

被引：507

作者：

ZAMORE, PD

PATTON, JG

GREEN, MR

机构：

[1] HARVARD UNIV, SCH MED, MOLEC & CELLULAR PHYSIOL LAB, BOSTON, MA 02115 USA

[2] UNIV MASSACHUSETTS, MED CTR, PROGRAM MOLEC MED, WORCESTER, MA 01605 USA

来源：

NATURE | 1992年 / 355卷 / 6361期

关键词：

D O I：

10.1038/355609a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A complementary DNA clone encoding the large subunit of the essential mammalian pre-messenger RNA splicing component U2 snRNP auxiliary factor (U2AF65) has been isolated and expressed in vitro. It contains two functional domains: a sequence-specific RNA-binding region composed of three ribonucleoprotein-consensus sequence domains, and an arginine/serine-rich motif necessary for splicing but not for binding to pre-mRNA.

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页码：609 / 614

页数：6

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