A GENERAL ENANTIOSELECTIVE SYNTHESIS OF ALPHA-ARYLETHYLAMINES

被引：41

作者：

CHEN, CP

PRASAD, K

REPIC, O

机构：

[1] Sandoz Research Institute East Hanover

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 49期

关键词：

ACETOPHENONES; ENANTIOSELECTIVE REDUCTION; MITSUNOBU REACTION; ALPHA-ARYLETHYLAMINES;

D O I：

10.1016/0040-4039(91)80469-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically active alpha-arylethylamines were prepared starting from acetophenones in greater-than-or-equal-to 95%ee and greater-than-or-equal-to 70% overall yield using oxazaborolidine catalyzed enantioselective reduction followed by the displacement of the hydroxy group by an azide group with clean inversion under Mitsunobu reaction conditions.

引用

页码：7175 / 7178

页数：4

共 12 条

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