AIRWAY WALL REMODELING IN ASTHMA - A NOVEL TARGET FOR THE DEVELOPMENT OF ANTIASTHMA DRUGS

被引：84

作者：

STEWART, AG ^{[1
]}

TOMLINSON, PR ^{[1
]}

WILSON, J ^{[1
]}

机构：

[1] ALFRED HOSP,DEPT THORAC MED,PRAHRAN,VIC 3181,AUSTRALIA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 07期

关键词：

D O I：

10.1016/0165-6147(93)90130-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The regulation of vascular smooth muscle proliferation has been examined extensively in recent years since the recognition that hyperplasia and hypertrophy of vascular smooth muscle are significant pathological features of hypertension and atherosclerosis. In this article, Alastair Stewart and colleagues discuss recent developments in the investigation of the pathology of asthma that indicate some parallels with the structural changes that occur in blood vessels in hypertension and atherosclerosis.

引用

页码：275 / 279

页数：5

共 39 条

[1] QUESTIONS ABOUT INHALED BETA-2-ADRENOCEPTOR AGONISTS IN ASTHMA [J].

BARNES, PJ ;

CHUNG, KF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (01) :20-23

[2]

BARNES PJ, 1986, LANCET, V1, P242

[3]

BARNES PJ, 1988, ASTHMA BASIC MECHANI, P415

[4] CELLULAR EVENTS IN THE BRONCHI IN MILD ASTHMA AND AFTER BRONCHIAL PROVOCATION [J].

BEASLEY, R ;

ROCHE, WR ;

ROBERTS, JA ;

HOLGATE, ST .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (03) :806-817

[5] NATURAL INHIBITOR OF TRANSFORMING GROWTH-FACTOR-BETA PROTECTS AGAINST SCARRING IN EXPERIMENTAL KIDNEY-DISEASE [J].

BORDER, WA ;

NOBLE, NA ;

YAMAMOTO, T ;

HARPER, JR ;

YAMAGUCHI, Y ;

PIERSCHBACHER, MD ;

RUOSLAHTI, E .

NATURE, 1992, 360 (6402) :361-364

[6] MYOFIBROBLASTS AND SUBEPITHELIAL FIBROSIS IN BRONCHIAL-ASTHMA [J].

BREWSTER, CEP ;

HOWARTH, PH ;

DJUKANOVIC, R ;

WILSON, J ;

HOLGATE, ST ;

ROCHE, WR .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 3 (05) :507-511

[7] HEPARAN SULFATE-DEGRADING ENZYMES INDUCE MODULATION OF SMOOTH-MUSCLE PHENOTYPE [J].

CAMPBELL, JH ;

RENNICK, RE ;

KALEVITCH, SG ;

CAMPBELL, GR .

EXPERIMENTAL CELL RESEARCH, 1992, 200 (01) :156-167

[8] MEDIATORS OF BRONCHIAL HYPERRESPONSIVENESS [J].

CHUNG, KF .

CLINICAL AND EXPERIMENTAL ALLERGY, 1990, 20 (05) :453-458

[9] EPITHELIAL-CELLS [J].

DAVIES, RJ ;

DEVALIA, JL .

BRITISH MEDICAL BULLETIN, 1992, 48 (01) :85-96

[10] C-FOS PROTOONCOGENE EXPRESSION IN BRONCHIAL BIOPSIES OF ASTHMATICS [J].

DEMOLY, P ;

BASSETSEGUIN, N ;

CHANEZ, P ;

CAMPBELL, AM ;

GAUTHIERROUVIERE, C ;

GODARD, P ;

MICHEL, FB ;

BOUSQUET, J .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1992, 7 (02) :128-133

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