PLASMA MORPHINE-3-GLUCURONIDE, MORPHINE-6-GLUCURONIDE AND MORPHINE CONCENTRATIONS IN PATIENTS RECEIVING LONG-TERM EPIDURAL MORPHINE

被引：5

作者：

SCHNEIDER, JJ

RAVENSCROFT, PJ

CAVENAGH, JD

BROWN, AM

BRADLEY, JP

机构：

[1] MT OLIVET HOSP,HOSPICE HOME CARE UNIT,BRISBANE,QLD 4169,AUSTRALIA

[2] PRINCESS ALEXANDRA HOSP,PAIN CLIN,WOOLLOONGABBA,QLD 4102,AUSTRALIA

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 34卷 / 05期

关键词：

MORPHINE; MORPHINE-6-GLUCURONIDE; MORPHINE-3-GLUCURONIDE; EPIDURAL;

D O I：

10.1111/j.1365-2125.1992.tb05651.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Plasma morphine concentrations were measured in five cancer patients receiving long-term epidural morphine administration. Peak concentrations were observed within 1 h of dosage and concentrations then declined biexponentially. Plasma morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) concentrations were measured in two patients and plasma M3G concentrations were observed to be much higher than plasma M6G and morphine concentrations. Peak plasma M6G concentrations occurred within 1.0 h of dosing and plasma M6G concentrations then remained higher than plasma morphine concentrations.

引用

页码：431 / 433

页数：3

共 9 条

[1] AN IMPROVED METHOD FOR THE SIMULTANEOUS DETERMINATION OF MORPHINE AND ITS PRINCIPAL GLUCURONIDE METABOLITES [J].