BIOCOMPATIBLE NEEDLE-TYPE GLUCOSE SENSOR WITH POTENTIAL FOR USE IN-VIVO

A biocompatible material with diffusion-limiting properties [(MPC-co-BMA)-CA] was prepared by mixing the copolymer of 2-methacryloyloxyethyl phosphorylcholine and n-butyl methacrylate (MPC-co-BMA) with cellulose acetate (CA). Investigation of the biocompatibility showed that, compared with CA, relatively few platelets bound to it and no morphological change was observed. This material was dip-coated as the outermost layer onto the working electrode of a needle-type glucose sensor. The sensor showed a rapid response (<120 seconds in batch operation), good reproducibility (RSD < 5%), good stability (more than 36 hours in control serum continuously), and a very wide dynamic range (0-1000 mg/dl glucose). it was used to determine glucose in serum. The data obtained from the sensor showed good agreement (R > 0.95) with that from a clinical autoanalyzer.