BIOLOGICAL-ACTIVITIES OF ANTI-IGE ANTIBODIES

被引：25

作者：

STADLER, BM ^{[1
]}

STAMPFLI, MR ^{[1
]}

MIESCHER, S ^{[1
]}

FURUKAWA, K ^{[1
]}

VOGEL, M ^{[1
]}

机构：

[1] UNIV BERN,INST CLIN IMMUNOL,CH-3000 BERN,SWITZERLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1993年 / 102卷 / 02期

关键词：

IGE; ANTI-IGE AUTOANTIBODY; FC-EPSILON-RI; CD23; IGE SYNTHESIS;

D O I：

10.1159/000236561

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Naturally occurring anti-IgE autoantibodies represent a heterogeneous mixture of antibodies with diverse specificities and biological functions. By using murine monoclonal anti-IgE autoantibodies directed against different epitopes on the IgE molecule as a model for autoantibodies, we could show that only a minority of antibodies combine all beneficial biological activities, such as the activity of inhibiting in vitro IgE synthesis, removing IgE from the surface of CD23+ cells and not being anaphylactogenic. While it is difficult to isolate and measure anti-IgE antibodies in human serum, it is now possible to generate such human anti-IgE antibodies by the method of repertoire cloning. Thus, human recombinant antibodies against IgE may become available for the treatment of atopic disease.

引用

页码：121 / 126

页数：6

共 38 条

[1] DETECTION OF IGG SUBCLASSES WITH ANTI-IGE ACTIVITY IN PATIENTS WITH ATOPIC DISEASES [J].