TUMOR-NECROSIS-FACTOR ALPHA PRODUCTION IS UP-REGULATED IN DIABETES PRONE BB RATS

被引：44

作者：

ROTHE, H

FEHSEL, K

KOLB, H

机构：

[1] Diabetes Research Institute, University of Düsseldorf, Düsseldorf

来源：

DIABETOLOGIA | 1990年 / 33卷 / 09期

关键词：

autoimmunity; BB rat; macrophages; tumour necrosis factor alpha;

D O I：

10.1007/BF00404147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Following activation peritoneal macrophages from diabetes prone BB rats secreted strikingly higher amounts of tumour necrosis factor alpha than found for macrophages from diabetes resistant or normal Wistar rats. Enhanced tumour necrosis factor alpha production was detected prior to the occurrence of insulitis. Cultures of macrophages derived from precursor cells in diabetes prone BB rat bone marrow also showed upregulated tumour necrosis factor alpha secretion upon challenge with endotoxin and interferon gamma. Tumour necrosis factor alpha hypersecretion may contribute to autoimmune diabetes by affecting thymic and post-thymic T-cell maturation and by promoting pancreatic islet inflammation. © 1990 Springer-Verlag.

引用

页码：573 / 575

页数：3

共 9 条

[1] ASSOCIATION BETWEEN HLA-DR2 AND PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-1 BY MONONUCLEAR-CELLS ACTIVATED BY LIPOPOLYSACCHARIDE [J].