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FELBAMATE REDUCES HYPOXIC-ISCHEMIC BRAIN-DAMAGE INVIVO

被引：79
作者：
WASTERLAIN, CG
ADAMS, LM
HATTORI, H
SCHWARTZ, PH
机构：
[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,SCH MED,BRAIN RES INST,LOS ANGELES,CA 90024
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 2-3期
关键词：
FELBAMATE; ANTICONVULSANTS; CEREBRAL ISCHEMIA; NEONATE; ASPHYXIA NEONATORUM; CEREBRAL INFARCTION;
D O I：
10.1016/0014-2999(92)90343-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neuroprotective effects of felbamate were tested in a model of incomplete cerebral ischemia and hypoxia in 7-day-old rat pups. Felbamate pretreatment (300 mg/kg) reduced the surface of infarcted cortex following bilateral carotid ligation, by 42-49% compared to saline and dimethylsulfoxide (DMSO) controls, respectively. The number of necrotic neurons in the dentate gyrus was reduced by 77% over both DMSO controls and saline controls. These results suggest that felbamate deserves further evaluation for its therapeutic potential in hypoxia-ischemia.
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页码：275 / 278
页数：4
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