PATELLAMIDE-A, A CYTOTOXIC CYCLIC PEPTIDE FROM THE ASCIDIAN LISSOCLINUM-PATELLA

被引：31

作者：

IN, Y ^{[1
]}

DOI, M ^{[1
]}

INOUE, M ^{[1
]}

ISHIDA, T ^{[1
]}

HAMADA, Y ^{[1
]}

SHIOIRI, T ^{[1
]}

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1994年 / 50卷

关键词：

D O I：

10.1107/S010827019300811X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of crystals of patellamide A{13-methyl-9,23-bis(1-methylethyl)-2,16-bis(1-methylpropyl)-14,-28-dioxa-7,21-dithia-3,10,17,24,29,30,31,32-octaaza-pentacyclo[24.2.1.1(5,8).1(12,15).1(19,22)]dotriaconta-1(29),5,-8(30),15(31),19,22(32)-hexaene-4,11,18,25-tetraone methanol solvate monohydrate, C35H49N8O6S2.-CH4O.H2O}, a cytotoxic cyclic peptide having a non-C2-symmetric methyl group, shows the C2-symmetric and saddle-shaped rectangular conformation where the methyl group is disordered into two C2-symmetric positions. The water and methanol solvents were located on the crystallographic diad axis and were held by hydrogen bonds and van der Waals contacts with the polar ring N atoms and non-polar D-Val side-chain atoms, respectively.

引用

页码：432 / 434

页数：3

共 8 条

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