INVESTIGATION OF ISOTHIOCYANATE ADDITION TO ALKYLIDENE DERIVATIVES OF MALONONITRILE AND CYANOACETIC ACID-ESTERS

Addition of arylisothiocyanates to active methylene compounds leads to a variety of compounds depending on the structure of the starting material and conditions used to conduct the addition. Addition of arylisothiocyanate to 1c leads to a pyrido[2,3-d]pyrimidine resulting from addition of a second mole of cyanate to the initial adduct. Addition of arylisothiocyanate to 1b led to a mixture of pyridine and thiopyran adducts, while addition to 1a led to open chain structures.