ABNORMAL BRAIN GLUCOSE-METABOLISM IN THE DELUSIONAL MISIDENTIFICATION SYNDROMES - A POSITRON EMISSION TOMOGRAPHY STUDY IN ALZHEIMER-DISEASE

被引:108
作者
MENTIS, MJ
WEINSTEIN, EA
HORWITZ, B
MCINTOSH, AR
PIETRINI, P
ALEXANDER, GE
FUREY, M
MURPHY, DGM
机构
[1] Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD
关键词
GLUCOSE BRAIN METABOLISM; DELUSION; DEMENTIA; FRONTAL LOBE; PARALIMBIC SYSTEM; LIMBIC SYSTEM;
D O I
10.1016/0006-3223(94)00326-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain lesions have been reported with increasing frequency in the delusional misidentification syndromes (DMS). This is the first controlled study to describe DMS regional cerebral metabolic rates of glucose (rCMRglc). We compared rCMPglc (using positron emission tomography) and neuropsychological data in 9 patients with DMS and Alzheimer dementia (AD), 15AD patients without DMS, and 17 healthy controls. The DMS group differed from the AD group without DMS in having significant hypometabolism in paralimbic (orbitofrontal and cingulate areas bilaterally) and left medial temporal areas, and significant bilateral normalized hypermetabolism in sensory association cortices (superior temporal and inferior parietal) without right left asymmetry. Compared to healthy controls, both AD groups had significant dorsolateral frontal hypometabolism bilaterally. No specific DMS neuropsychological profile was identified. Dysfunctional connections among multimodal association areas, paralimbic structures, and dorsolateral frontal cortex are proposed as the predisposing neural deficit underlying DMS, causing cognitive-perceptual-affective dissonance, which under specific conditions result in ''positive'' delusion formation.
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页码:438 / &
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